By D. Scott Linthicum, Nadir R. Farid
Here is an updated overview of significant new tools and leads to anti-idiotypes, receptors, and molecular mimicry.It starts off with a dialogue of the theoretical historical past ofthe anti-idiotypic community, it really is function within the rules of immune reaction, and the actual features of anti-idiotypic antibodies. It then is going directly to discover many exciting purposes in such parts as insulin motion, thyroid phone functionality, the neurosciences, cardiology, virology, pharmacology, and copy.
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Extra info for Anti-Idiotypes, Receptors, and Molecular Mimicry
As these binding specificities are mediated by the variable regions, an examination of the structure and distribution of the idiotypes characterizing these paraproteins may extend our understanding of the phenomena. Recently, 10 of 12 monoclonal IgM rheumatoid factors (RFs) were shown to possess a cross-reactive idiotope by virtue of reactivity with an anti-idiotype raised against a synthetic peptide derived from the second hypervariable region of the light chain of the IgM-RF Sie (4). However, similar studies with an anti-idiotype produced against a peptide of the third hypervariable region of the heavy chain defined a private, dominant idiotope present only on the immunoglobulin from which the peptide sequence was derived (5).
Edmundson. 1978. Interconversion of conformational isomers of light chains in the Mcg immunoglobulins. Biochemistry 17: 148. 14. L. R. B. Edmundson. 1973. 5-A. resolution. Biochemistry 12:4620. 15. R. E. Abola, M. Schiffer, and N. Panagiotopoulos. 1975. Rotational allomerism and divergent evolution of domains in immunoglobulin light chains. Biochemistry 14:3953. 16. , and N. Hilschmann. 1971. Die vollstandige Primar-struktur einer monoklonalen immunoglobulin-I-Kette von I-Typ, Subgruppe II (Bence-Jones Protein ViI).
Antibodies to the binding site of the LHRH receptor: generation with a synthetic decapeptide encoded by a RNA complementary to LHRH mRNA. Proc. Natl. Acad. Sci. USA, 83:9714. 14. J. Catt. 1985. Photoaffinity labeling of pituitary and gonadal receptors for gonadotropin-releasing hormone. Endocrinology 117:738. 15. L. E. Blalock. 1987. Generation of idiotypic and anti-idiotypic antibodies by immunization with peptides encoded by complementary RN As: A possible molecular basis for the network theory.
Anti-Idiotypes, Receptors, and Molecular Mimicry by D. Scott Linthicum, Nadir R. Farid