New PDF release: Animal Models of Depression

By William T. McKinney (auth.), George F. Koob PhD, Cindy L. Ehlers PhD, David J. Kupfer M.D. (eds.)

ISBN-10: 146846762X

ISBN-13: 9781468467628

ISBN-10: 1468467646

ISBN-13: 9781468467642

Animal versions characterize experimental investigations constructed in a single species for the aim of learning phenomena in one other species and supply a number of benefits for preclinical learn. they permit scientists larger regulate and isolation of significant experimental variables. Animal versions are secure, reproducible recommendations through which to judge and layout new pharma­ cological therapy suggestions, whereas additionally permitting direct critical frightened method intervention to change the process the aberrant habit. Animal versions were constructed for a few psychological health problems; during this specific area, they carry the promise to make clear the nonetheless vague etiologies of those health problems and finally to facilitate the advance and checking out of "cures. " but, precise types of psychological disease are tricky to boost, simply because psychological disorder could be a uniquely human phenomenon. It used to be in keeping with those issues that the MacArthur origin study community at the Psychobiology of melancholy got down to sponsor a convention to study the prestige, difficulties, gives you, and relevance of animal versions to the scientific stipulations of affective problems. The convention was once held in September 1986 and incorporated members from either in the community in addition to scientists and students from numerous disciplines appropriate to the troubles of the convention. After the convention was once held, it grew to become transparent to the organizers that the cloth awarded may be important to a broader box of investigators, due to the fact that a good portion of the knowledge has no longer been awarded in different places or within the unified context of a monograph.

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I • 120 200 ,. 2«1 «I • 120 200 2«1 ·10 10 20 30 TIME AHU INJECTION DAY 7 TIME AFTEII INJECTION DAY 7 «I ,. 1. Female rats are more sensitive to the effects of cocaine than male rats. p. , behavioral sensitization). The same once-daily dose of cocaine that had little effect on day 1 produces robust effects by days 7 or 10. 0 mg/kg Co_ ..... 1 mg/kg Co...... ,. 200 2«1 «I 120 ACTIVITY DAY 1 V£~TICAL !.! :;: 10 . u ;:: c ~ c ;; 110 ~ 2«1 34 Robert M. B. Weiss and the magnitude of hyperactivity, and stereotypy.

1973) patients who were administered carbamazepine, indicated that clinical trials of carbamazepine in affective illness might provide an alternative therapy for unresponsive patients (Ballenger and Post, 1978b, 1980). , 1984a, 1986d,e). , 1984d; Post, 1987). In addition, one can also ask whether some of the initial rationales for the use of carbamazepine are in fact relevant and, in particular, is the ability of carbamazepine to dampen neural activity in the limbic system related to its mechanism of action in manic-depressive illness?

Animal Models: Promises and Problems 23 the neurochemical change as a result of the bulbectomy, the neurochemistry of depression might be understood. The advantage of a completely homologous model is that it probably would not only contribute to the understanding of the brain biochemistry of depression but would lead to the development of effective drugs for treating the disease. Do such models of depression currently exist? The answer is probably yes but only for some types of human depression.

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Animal Models of Depression by William T. McKinney (auth.), George F. Koob PhD, Cindy L. Ehlers PhD, David J. Kupfer M.D. (eds.)


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