By Ronald R. Watson (auth.), Ronald R. Watson (eds.)
Alcoholism, the oldest addictive disorder, is still a major challenge as a result of its significant alterations of many physiological structures. The genetic and neurological origins and mechanisms are complicated and merely in part understood. even if, it really is transparent that alcohol use modifies the creation of so much hormones, without delay and not directly modulating the structures that hormones control. Acute and persistent alcohol intake impacts almost all mobile capabilities of tissues like mind, liver, immune procedure, and reproductive and endocrine organs. The latter have significant regula tory roles, affecting many capabilities from improvement to repro duction. even though pressure can additional adjust alcohol's results on hormone creation, it considerably reasons so much of alcohol's modi fications of the physique to ensue through alterations in hormone creation and secretion. Ronald R. Watson vii participants Michael L. Adams • division of Psychiatry, Washington collage college of drugs, St. Louis, MO Robert A. Anderson, Jr .• Ob/Gyn examine, Rush-Presbyterian-St. Luke's clinical middle, Chicago,IL Kasibhatla Bhavani • Molecular Heptology Laboratory, Massachusetts common health facility melanoma heart, Harvard scientific college, Charlestown, MA Theodore J. Cicero • division of Psychiatry, Washington college institution of medication, St.
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On the other hand, if they have identical neurochemical profiles, then it seems highly likely that only one receptor would be involved in their endocrine effects. Using this more sophisticated approach to receptor pharmacology, it should be possible to examine more carefully the issue of whether one or more opioid receptor is involved in endocrine function and, of equal significance, to examine the potential mechanisms involved in their action on specific endocrine systems. In the ensuing discussion, we will delineate the attempts thus far carried out using the techniques described above in an attempt to determine which opiate receptor subtypes, particularly K and 1-1, are involved in the effects of opiates on the endocrine system.
1anecki and A. Steinberger (1986) Polarized Sertoli cell functions in a new two-compartment culture system. 1. Androl. 7,69-71. 1421. Weinberg and A. W. Vogl (1988) Effects of ethanol consumption on the morphology of the rat seminferous epithelium. 1. Androl. 9,261-269. 1431. M. Frasor, R. A. Anderson, and L. D. Russell (1992) Ethanol impairs secretory activity of Sertoli cells in conventional and bicameral culture. BioI. Reprod. 46(Suppl. 1), 171. I"F. Diamond, L. Ringenberg, D. Macdonald, 1. Barnes, C.
20 Anderson 141 A. 1anecki and A. Steinberger (1986) Polarized Sertoli cell functions in a new two-compartment culture system. 1. Androl. 7,69-71. 1421. Weinberg and A. W. Vogl (1988) Effects of ethanol consumption on the morphology of the rat seminferous epithelium. 1. Androl. 9,261-269. 1431. M. Frasor, R. A. Anderson, and L. D. Russell (1992) Ethanol impairs secretory activity of Sertoli cells in conventional and bicameral culture. BioI. Reprod. 46(Suppl. 1), 171. I"F. Diamond, L. Ringenberg, D.
Alcohol and Hormones by Ronald R. Watson (auth.), Ronald R. Watson (eds.)